In general, it can be difficult to get any job if you have a criminal record. However, a DUI conviction can make an already uncomfortable situation, untenable.
Having a DUI on your record can automatically disqualify you from a number of jobs to include bus driving, teaching, law enforcement, truck driving, outside sales, etc. Furthermore, DUI convictions can limit your opportunities to work with government agencies, government contractors, and the like.
Source: https://www.entrepreneurshipsecret.com/jobs-you-cant-get-with-a-dui/